Pt 1 due in 5 Hours!!! HW

Business Important Shaft: 4/1/19 150 min
Time to indicate the screenwriter aupstbusiness where you catch what you apprehobject and subjoinuce it in a dialogical condition. Rectotal that this instrument that you must freason clew provisions (observe the commendatory page of this module control a roll of apt provisions).
Imagine a talk betwixt 3-4 businessists from this provision. The talk can go from a upstbusiness clue of the Laocoon, a upstbusiness application of mathematics or engineering, to complaints abextinguished your supporter.
The important shaft obtain be this talk and the couple required rejoinder shafts should comprise your critiques as the truthful consultant control this film. Gundivided this is quiescent a controlmal match assignment control this assort, rectotal to comprise in-text extract where it is expedient, which comprises your avow paraphrases.

Business Peer Rejoinder 1: 4/3/19 100 min
Gus – mathematician
Eren – mathematician
Ray – mathematician
Roberto- businessist 
Gus- Hey everyundivided how are you guys doing today? Anything upstart?
Eren- Hey Gus, Iv been doing august and Iv been apprehending we insufficiency to correct our math skills and Iv been apprehending of referable attribuboard attributableability upstbusiness excluding its bark of perplexed.
Gus- And what is it?
Ray- Well-behaved-behaved Eren and I were apprehending of a habit we could unite everything up by referable attribuboard attribuboard attribuboard having to subjoin total the sides its denominated multiplicity. It would be a august habit to meet the area of an business ingredient and instead of subjoining total the sides of an business ingredient you expatiate the diffusiveness and the width of the business ingredient
Gus- Well-behaved-behaved that sounds august ,excluding wouldn’t that honorable be with business ingredients that are squared and rectangular shaped?
Eren- You do accept a apex we accept to countenance that extinguished excluding control now that’s total we accept.
Roberto- Yes I tally that would perform my estate considerable easier by measuring my altarpieces. I apprehobject referable attribuboard attribuboard attribuboard simply would it perform my estate easier excluding as-well-behaved total the other businessists during this 16th antiquity.
Ray- I tally with you Roberto I apprehobject everyundivided can profit from this.
Kleiner, Fred S. “Gardner’s Business Through the Ages – A Concise Global History.” Fourth Edition. Cengage. 2017. Print.

Business Peer Rejoinder 2: 4/3/19 100 min
Jan face Eyck: (comes into hipster coffee ammunition where Rogier and Hugo are sitting in vegan leather armchairs and sipping on concentratively sourced, non-GMO, farm to board, constitutional, gluten at-liberty, lactose at-liberty, at-liberty concatenate, beautiful employment, sustainable cappuccinos). Sup dawgs? 
Rogier face der Weyden: (laughing) No undivided talks love that gundivided Duccio di Buoninsegna painted Estate of Jesus. 
Hugo face der Goes: Hey Jan how’s it going? How’s operation?
Jan: (nod a cappuccino as-well-behaved accordingly it’s honorable what’s unnaturalnessufactured). Everything’s amiable, objectowment control question. You apprehend, I quiescent can’t appreciate that a blunt nobody businessist love me landed a lesson operationing control Philip the Amiable.
Hugo: Come on, you’re a august businessist. The Ghent Altarpiece is going to be a masterpiece!
Jan: Objectowment unnaturalness. I do love how it’s hence along. The poylptychs are turning extinguished entirely.
Rogier: Poly.. whats?
Jan: polyptychs. They’re a course of paintings on hinged panels. They’re unblemished control exchange ingredients cuz you can inclose them.
Hugo: Hopeful. Super hopeful. Can’t continue to observe the perfect fruit. 
Jan: Well-behaved-behaved that’s probably referable attribuboard attribuboard attribuboard going to supervene accordingly I wither in 1441 and you’re referable attribuboard attribuboard attribuboard veritably abquenched until 1441. So… that’s clumsy. 
Rogier: (almost falls extinguished of chair accordingly he’s laughing so grievous) Burn!!! He got you amiable, Hugo.
Hugo: (clumsy laugh). Well-behaved, whether you’re departed or referable attribuboard attribuboard attribuboard my Adoration of the Shepherds is going to be a pompous chance with the realistic portraits on the triptych. It obtain be regarded as flashing.
Jan: I don’t hesitate it, my confidant. And let’s referable attribuboard attribuboard attribuboard controlget Rogier. Buddy, judge us encircling Deposition.
Rogier: Control knowing. It is going to observe a fate love a distorted shrine. I love to condense the countenances in my paintings so there is the sensation of move and exercise. As-well, I localize a flimsy meafirm with single-minded excluding meaningful elucidation and perspective. It obtain accept august cohesion. Super duper meaningful and affecting.
Jan: Hopeful. Hopeful. (nods and sips inopposed overpriced espresso)
Kleiner, Fred S. “Gardner’s Business Through the Ages – A Concise Global History.” Fourth Edition. Cengage. 2017. Print.

Business Slides: 4/2/19 Well-behaved-behaved written vindications***
There are three slides perform knowing you vindication each countenance of the Prompt *observe benevolence*

Bio Important Prompt: 4/3/19 250 min
An object to hebusiness quackery? Referable attribuboard attribuboard attribuboard completely. A upstbusiness assort of cholesterol gloomy garbages denominated PCSK9 inhibitors (Links to an exterior locality.)Links to an exterior locality. is veritably amiable at gloomy LDL razes, excluding testimony of how well-behaved-behaved it reduces the portraiture of hebusiness quackery is referable attribuboard attribuboard attribuboard so lucid. From this Upstbusiness York Times businessicle, debate the problems treating a obscure quackery love hebusiness quackery. Meet counsel abextinguished familial hypercholesterolemia and what opposed matter libertys would be advantageous, regarding that seven opposed genes are apprehendn to supply to this quackery (OMIM 143890 (Links to an exterior locality.)Links to an exterior locality.).  In your shaft, decipher or unitemarize why the upstbusiness garbage Repatha is so potent in reducing LDL cholesterol, and then glean undivided of the genes from OMIM (observe the Phenotype-Gene Relationship board) and debate undivided reason of hypercholesterolemia and practicable matter liberty, inveterate on the gene you gleaned.

Bio Peer Rejoinder: 4/5/19 100 min
A upstbusiness LDL garbage was objectorsed and the researchers had very proud expectations and were rooting control the object of hebusiness quackery. With a cethcoming con-over of this upstbusiness garbage conducted to patients, it had simliar profits love a statin. Control patients who don’t judgment or do judgment the proud compensation of this garbage, it has been suggested to continue control long-term results when past and past crowd stbusiness to reason it. The problems of this quackery is that they “are referable attribuboard attribuboard attribuboard integralied to statins at total…[you’ll insufficiency a] master to state what’s veritably causing [the] symptoms. And some crowd endure undivided statin ameliorate then another.” (Krumholz, H., 2017) This garbage is so potent in treating hebusiness quackery accordingly typically dozes of this medication is 90 mg/dl (this is considered inaudible) and using Repatha is 30 mg/dl. 
“Familial hypercholesterolemia is an autosomal dominant quackery characterized by altitude of serum cholesterol fendanger to inaudible density lipoprotein (LDL), which promotes deeposition of cholesteral in the bark, tendons, and coronary businescourse (Hobbs et al.. 1992, OMIM)” This can supervene in twain homozygous and heterzygous. Houlston, R. et al. 1988, total discovered that that patients coronary businessery quackery accept a proud raze of LDL ardor in contrariety of those who don’t accept coronary businessery quackery. This suggests “that [LDL] measurements may acceleration prophesy the endanger of coronary hebusiness quackery in beings with familial hypercholesterolemia.” Matter control this is chaning estatestyle love exercising and consuming a “healthy inaudible-fat withert”.
RESCOURCES:
https://www.nytimes.com/2017/03/20/health/ldl-cholesterol-heart-disease-drugs-pcsk9-inhibitors.html?rref=collection%2Fsectioncollection%2Fscience&action=click&contentCollection=science&region=stream&module=stream_unit&version=latest&contentPlacement=4&pgtype=sectionfront (Links to an exterior locality.)Links to an exterior locality.
https://www.omim.org/entry/143890 (Links to an exterior locality.)Links to an exterior locality.
https://www.mayoclinic.org/diseases-conditions/familial-hypercholesterolemia/diagnosis-treatment/drc-20353757 (Links to an exterior locality.)

Bio Questions: 4/4/19
1. Unnaturalnessy beings with metabolic quackerys are usual at source excluding profession symptoms soon thereafter. Why?
2. Roll the habits in which a metabolic stop can accept phenotypic goods.
3. If phenylalanine was referable attribuboard attribuboard attribuboard an leading amino aculeated, would withert therapy (the egress of phenylalanine from the withert) control PKU operation? Do referable attribuboard attribuboard attribuboard honorable tell yes or no. Give a blunt interpretation.
4. Describe the quaternary edifice of the class protein hemoglobin.
5. Transcriptional conductors are proteins that oblige to promoters (the 5’ flanking regions of genes) to organize their transcription. Assume that a detail transcription conductor usually promotes transcription of gene X, a bliss protein. If a contradiction performs this conductor gene nonfunctional, would the resulting phenotype be resembling to a contradiction in the gene X itself? Why or why referable attribuboard attributable?

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