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Posted: July 30th, 2023
Oxygen, an essential element for human life, plays a critical role in our daily existence. It is vital for the process of respiration, allowing us to extract energy from our surroundings. The human circulatory system efficiently carries oxygen to the cells within the body through a process known as diffusion, where it spreads from areas of high concentration to low concentration.
In the human body, oxygen is transported primarily by two means: dissolved in plasma, accounting for about 1.5%, and bound to hemoglobin, which makes up approximately 98.5%. Hemoglobin (Hb) is a crucial protein responsible for carrying oxygen in the blood.
The efficiency of oxygen loading onto hemoglobin is influenced by several factors:
Temperature: Higher temperatures facilitate a faster dissociation of oxygen from hemoglobin, while lower temperatures inhibit oxygen dissociation.
pH: Low pH levels lead to the dissociation of oxygen from hemoglobin, while high pH levels inhibit this process.
BPG (2,3-bisphosphoglycerate): This molecule, produced as a by-product of glycolysis, promotes the release of oxygen from hemoglobin. BPG binds to deoxyhemoglobin, reducing hemoglobin’s affinity for oxygen.
pCO2 (partial pressure of carbon dioxide): Increased levels of carbon dioxide in the blood lead to a decrease in pH due to the formation of hydrogen ions. This low pH reduces hemoglobin’s affinity for oxygen.
Understanding these factors is crucial for comprehending the complex mechanisms involved in oxygen loading and unloading in the body.
Reference:
Anatomy and Physiology by J. Gordon Betts, publication date 06/02/2021, “Physiology, Carbon Dioxide Transport.” National Center for Biotechnology Information, 1 Sept. 2020, www.ncbi.nlm.nih.gov/books/NBK532988.
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